Manchester City, on the other hand, are the clear favorites, and after their recent defeat to Brighton, they will be looking to pick up the much-needed three points. The team will be coming out strong against the German side, who have been struggling under manager Martin Demichelis.
For Leipzig, Assan Ouedraogo and Marc Guiu are still recovering from injuries, while Maxime Esteve is doubtful with a knock. Manchester City, however, has a relatively injury-free squad, with the only absence being Antoine Semenyo.
RB Leipzig's predicted line-up includes Vandevoordt in goal, with Baku, Orban, Lukeba, and Raum in defense. In midfield, Seiwald and El Aynaoui will likely start, while Gruda, Nkunku, and Nusa will make up the attacking trio. Romulo will likely start on the left wing.
Manchester City's predicted line-up includes Donnarumma in goal, with Lewis, Khusanov, Dias, and Gvardiol in defense. In midfield, Anderson and Fernandez will likely start, while Foden, Cherki, and Ndiaye will make up the attacking trio. Haaland will likely start up front.
The match is scheduled to kick off at 20:00 UK time at the Red Bull Arena.
Manchester City has a strong record against RB Leipzig, having won four of their six previous meetings, with one draw and one Leipzig victory. They have also won 21 of their 32 Champions League matches against German opposition.
RB Leipzig, on the other hand, has struggled against English clubs, having lost their last five European matches against them. They have also conceded 10 goals across their heavy defeat
